The ingredient your skincare routine is probably missing PDRN — Polydeoxyribonucleotide — is derived from salmon DNA and has been used in clinical dermatology for decades for its skin-regenerating and hydrating properties. medicube brings it into a daily serum format alongside peptides and niacinamide for a formula that works at the skin barrier level, not just on the surface.
What it does
- PDRN (salmon DNA) supports skin hydration and repair at the cellular level — the same active used in professional aesthetic treatments, now in a leave-on daily serum format
- Peptides signal the skin to support its own firmness and elasticity over time — with consistent use, skin looks and feels more structured and resilient
- Niacinamide (Vitamin B3) brightens uneven skin tone, reduces the appearance of dark spots and redness, and strengthens the skin barrier for improved moisture retention
- 10-layer hyaluronic acid complex delivers hydration at multiple depths of the skin — from surface plumping to deeper moisture retention throughout the day
- Lightweight, fast-absorbing pink serum texture layers cleanly under moisturizer and SPF without pilling or feeling heavy
Why people use it
- Fragrance-free, low-irritation formula suitable for daily use on sensitive, combination, oily, and dry skin types
- Addresses three skin concerns in one serum — hydration, firmness, and uneven tone — reducing the number of active products needed in a routine
- From medicube, one of Korea’s fastest-growing skincare brands — known for high-concentration actives at accessible price points
- Pairs with the medicube Booster-H device for enhanced ingredient penetration and more visible results
What to know
- Apply after toner, before moisturizer — use morning and/or evening depending on your routine
- PDRN is derived from salmon — not suitable for those with fish allergies; patch test before first use
- Consistent daily use over 4–8 weeks produces the most noticeable improvement in tone and texture
What to use it for
- Daily hydration and skin barrier support as a core serum step
- Targeting uneven skin tone, dullness, and early signs of loss of firmness
- A K-beauty active serum upgrade for those ready to move beyond basic moisturizer-only routines
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